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RANTES片段阻断艾滋病病毒进入细胞
来源 前沿医学资讯网 2011-4-6 9:13:09 （生物谷Bioon.com）
科学家已经研制出一种可以阻止艾滋病病毒（HIV）进入细胞的新蛋白质。该蛋白是基于体内自然产生的一种能够保护细胞不受病毒侵害的蛋白质。与此不同的是该人造蛋白在其抑制艾滋病所需剂量不会导致炎症和其他副作用。在与艾滋病的斗争中该发现可能是一个潜在突破，也为新药的合理设计作出巨大贡献。该研究结果于2011年4月发表在《FASEB Journal》上。
FASEB Journal的主编Gerald Weissmann博士说：“该研究将科幻转变为现实，研究人员将一种蛋白质拆解成各部分，去掉有害部分，然后对具有治疗效果的部分进行稳定和修改。这不仅对艾滋病人是好消息，对我们也是如此，因为这为许多其它疾病相似的研究铺平了道路。”
该蛋白片段基于体内自然产生的蛋白质RANTES，其是人体免疫系统的一部分。 RANTES可以帮助机体对HIV或AIDS作出自然防御，但不能作为药物或候选药物来使用，因为它有多种可导致有害的炎症反应的其他生物效应。经过对RANTES蛋白精确的分子结构进行检测以后，研究人员发现实际上只有一小片段RANTES蛋白在阻止艾滋病毒进入细胞中起作用。他们对RANTES蛋白中所需的部分进行分割，并努力稳定且不损害其保护效应。
经过几个连续步骤地分子细化和一些虚拟建模，研究人员创建了一种能够强力对抗HIV的肽。对如关节炎、红斑狼疮等炎症性疾病的治疗以及器官移植排斥反应的预防可能带来受益。
Weissmann 说：“我们终于能够设计出一种定向标靶的智能抗HIV药物。这是因为科学家们花了几十年的时间对病毒是如何进入细胞的分子细节进行研究，包括其确切的化学结构。 如同文艺复兴时期的雕塑家将粗糙大理石变成艺术品一样，今天的分子工程师...用智慧设计并创造拯救生命的化学杰作。”
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| 图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
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RANTES fragments block the AIDS virus to enter cells
Source of cutting-edge medical information network 2011-4-6 9:13:09 (Bio Valley Bioon.com)
Scientists have developed a virus can prevent AIDS (HIV) into cells of new proteins. The naturally occurring proteins is based on a body to protect cells from viruses of the protein. And this difference is that the artificial protein required dose of AIDS in the inhibition of inflammation and other side effects will not lead. In the fight against AIDS in the findings may be a potential breakthrough for the rational design of new drugs make a significant contribution. The study was published in April 2011 in the "FASEB Journal" on.
FASEB Journal, Dr. Gerald Weissmann, editor in chief, said: "The study will be science fiction into reality, the researchers disassembled into various parts of a protein, remove the unwanted part, then part of a treatment effect of stability and change. This is not only AIDS is good news for us, too, because it is similar to many other diseases, research has paved the way. "
The body naturally occurring protein fragment of the protein on RANTES, it is the part of the body's immune system. RANTES can help the body to make natural defense HIV or AIDS, but not as a drug or drug candidate to use, because it has a variety of inflammatory response can lead to other harmful biological effects. After a precise molecular structure of RANTES protein were detected, researchers found that in fact only a small fragment of RANTES protein in preventing HIV enters cells work. RANTES protein in their part of the required partition, and efforts to stabilize and without prejudice to its protective effect.
After several consecutive steps to refine and some virtual molecular modeling, the researchers created a peptide can be potent against HIV. On such as arthritis, lupus and other inflammatory diseases and the prevention of organ transplant rejection may bring benefit.
Weissmann said: "We are finally able to design a targeted anti-HIV target smart drugs. This is because scientists have spent decades on the virus to enter cells, the molecular details of how to conduct research, including the exact chemical structure . like Renaissance sculptors, like the rough marble into works of art, today ... with the wisdom of the molecular design engineer and create a masterpiece of life-saving chemicals. "
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