科学家找到一种艾滋病治疗全新方法
——可杀灭隐藏在免疫细胞内的病毒
2009年06月22日08:30 来源:《科技日报》
本报多伦多6月20日电(记者杜华斌)加拿大和美国的研究人员找到了一种治疗艾滋病全新方法。新方法将定向化疗方法与目前较为普遍使用的高效抗逆转录病毒疗法结合使用,为治疗艾滋病提供了一个新的可能。
据参与研究工作的科学家介绍,这种新的治疗方法既可以杀灭在人体内四处游荡的病毒,还能够杀灭隐藏在免疫细胞内的病毒。该项研究成果的价值在于它为全世界研究艾滋病治疗的科学家指明了前进的方向,为找到一种全新的具有创新性的艾滋病治疗方法奠定了基础。相关文章发表在6月21日出版的《自然医学》杂志上。
迄今为止,抗艾滋病治疗的疗效一直不甚理想,原因是病毒隐藏在免疫系统细胞里,而目前使用的高效抗逆转录病毒疗法对躲藏在免疫细胞内的病毒无计可施。加拿大和美国的研究人员成功地识别出那些躲藏有病毒的细胞,找到了病毒可以逃避现有治疗的“隐身”机理。
参与研究工作的麦吉尔大学血液学家基恩·罗迪教授认为,该项研究成果首次证明所谓的艾滋病病毒潜伏池现象并不是因为抗逆转药物缺乏效力,而是由于病毒隐藏在两种不同类型的长寿命CD4记忆免疫细胞内。艾滋病病毒潜伏池有几种类型,每一种类型潜伏池都需要不同的治疗方法来消除它们。一旦病毒隐藏在这些潜伏池细胞里,它们就会对其产生依赖。如果细胞存活,病毒就可以存活,但如果细胞死亡,则病毒也无法存活。因此,消灭这些免疫细胞就能够杀灭这些隐藏其中的病毒。现存的高效抗逆转录病毒疗法可以杀灭在体内流传的病毒,但是无法对付隐藏在潜伏池细胞内的病毒。
主持研究工作的蒙特利尔大学塞卡里教授表示,该研究结果与用于治疗白血病采取的策略相似,即同样是定向化疗,并同时与定向免疫治疗相结合。这种方法既可以杀灭细胞中的病毒,同时也为免疫系统留出时间再生健康细胞。
研究人员认为,目前所得到的成果为开发出全新的抗艾滋病毒治疗方法提供了一个重要的选项,但要进入实际应用还需要若干年进一步的研究工作。
Scientists find a new method of AIDS treatment
- Can be hidden in immune cells to kill the virus
At 8:30 on June 22, 2009 Source: "Science and Technology Daily"
Newspaper in Toronto June 20 (Xinhua Du Huabin) of Canada and the United States, researchers found a new method of treatment of AIDS. New methods will be targeted chemotherapy with the more commonly used in the current highly active antiretroviral combination therapy for treatment of AIDS has provided a new possibility.
According to the scientists involved in research presentations, this new treatment can kill wandering around in the body of the virus, also hidden in immune cells to kill the virus. The value of the results of the study lies in its study of AIDS treatment around the world the scientists pointed out the way forward, in order to find a new innovative treatment of AIDS foundation. Related Articles published in the June 21 issue of "Nature Medicine" magazine.
To date, the efficacy of anti-AIDS treatment has been less than ideal because the virus hidden in the immune system cells, while the currently used highly active antiretroviral therapy on immune cells hiding in the virus can not do anything. Canada and the United States, the researchers successfully identified a virus that hide the cells, found the virus to evade the existing treatment of the "stealth" mechanism.
To participate in the research work of McGill University professor of blood基恩罗迪scientists believe that the first results of the study prove that the so-called latent pool of HIV is not due to lack of effectiveness of anti-retroviral drugs, but because the virus hidden in two different types of long-lived memory CD4 immune cells. Latent pool of HIV There are several types, each type of latent pools require different treatment methods to eliminate them. Once the virus hidden in the potential pool of these cells, they will rely on their produce. If the cells survive, the virus can survive, but if the cell death, the virus can not survive. Therefore, the elimination of these immune cells can kill one of these hidden viruses. Existing highly active anti-retroviral therapy can kill the virus circulating in the body, but were unable to deal with hidden cells in the latent pool of virus.
The auspices of the University of Montreal research, Professor塞卡里said the study results and for the treatment of leukemia is similar to the strategy adopted, which is also targeted chemotherapy, and at the same time with a combination of targeted immunotherapy. This method can kill the virus cells, as well as the immune system time to stay healthy cell regeneration.
The researchers believe that the results obtained for the development of a new anti-HIV treatment provided an important option, but to enter the practical application of a number of years also needs further research.
|