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艾滋病研究也有了划时代的意义 杀死病毒不成问题
http://www.e23.cn2010-8-24科技日报
摘 要：目前用于癌症早期和癌症治疗的两种药物胞苷（decitabine）和健泽（gemcitabine）配合使用，有望有效地治疗艾滋病。在实验鼠动物模式研究中，混合药物能够导致艾滋病病毒发生变异并死亡，科学家称其为“致命性变异”。
舜网讯 美国明尼苏达大学医疗中心科学家日前表示，他们发现美国食品和药物管理局批准的、目前用于癌症早期和癌症治疗的两种药物胞苷(decitabine)和健泽(gemcitabine)配合使用，有望有效地治疗艾滋病。在实验鼠动物模式研究中，混合药物能够导致艾滋病病毒发生变异并死亡，科学家称其为“致命性变异”。
新发现对艾滋病研究具有划时代的意义，因为这是人们首次寻找到无毒性副作用对付艾滋病病毒的方法。科学家相信，由于胞苷和健泽是两种获准使用的药物，因而如果他们的研究结果在大的实验动物模型上也行之有效的话，那么将比较容易地加速开发出适合于人体的药物。
研究参与人员包括分子病毒研究所和牙科学院的分子病毒学家路易斯·曼斯基博士和克莉丝汀·克劳瑟博士，以及药物设计中心药物化学家史蒂文·帕特森博士。曼斯基表示，他们的发现为最终帮助全球3300万艾滋病病毒携带者解除病症带来了希望。相关文章发表在近期的《病毒学》杂志网站上。
艾滋病病毒在人体内变异和演变迅速。现在常用的药物主要作用是抑制病毒的生长和复制，胞苷和健泽组成的新药物的作用则正好相反，它迫使病毒发生变异失控，并走向灭亡。曼斯基说，艾滋病病毒的变异能力使得人们难以捕捉并对付它，“我们利用了病毒的这一行为，通过促进病毒变异率，让病毒本身作为武器攻击自己”。
科学家发现，他们用来杀灭艾滋病病毒所需药物的浓度对细胞无可检测出的毒性，与此同时，用于有效杀灭实验室培养的艾滋病病毒的药物浓度远低于人们用这两种药治疗癌症时的药物浓度。现有获准使用药物被用来开发治疗其他疾病的方法，在医学界被认为是一种低成本和快速获取新药的途径，称为药物重新定位(drug repositioning)。
据悉，胞苷和健泽已获准进行实验鼠的前期临床实验，初期的发现确认，药物可作为艾滋病病毒有效的抗病毒治疗方法。目前科学家正在调整药物，以便组成能够被人体吸收的抗艾滋病病毒口服药。
胞苷和健泽合用可杀艾滋病病毒
发布时间： 2010-08-24 | 作者：毛黎
http://www.stdaily.com 2010年08月24日 来源： 科技日报 作者： 毛黎
本报华盛顿8月20日电（记者毛黎）美国明尼苏达大学医疗中心科学家日前表示，他们发现美国食品和药物管理局批准的、目前用于癌症早期和癌症治疗的两种药物胞苷（decitabine）和健泽（gemcitabine）配合使用，有望有效地治疗艾滋病。在实验鼠动物模式研究中，混合药物能够导致艾滋病病毒发生变异并死亡，科学家称其为“致命性变异”。
新发现对艾滋病研究具有划时代的意义，因为这是人们首次寻找到无毒性副作用对付艾滋病病毒的方法。科学家相信，由于胞苷和健泽是两种获准使用的药物，因而如果他们的研究结果在大的实验动物模型上也行之有效的话，那么将比较容易地加速开发出适合于人体的药物。
研究参与人员包括分子病毒研究所和牙科学院的分子病毒学家路易斯·曼斯基博士和克莉丝汀·克劳瑟博士，以及药物设计中心药物化学家史蒂文·帕特森博士。曼斯基表示，他们的发现为最终帮助全球3300万艾滋病病毒携带者解除病症带来了希望。相关文章发表在近期的《病毒学》杂志网站上。
艾滋病病毒在人体内变异和演变迅速。现在常用的药物主要作用是抑制病毒的生长和复制，胞苷和健泽组成的新药物的作用则正好相反，它迫使病毒发生变异失控，并走向灭亡。曼斯基说，艾滋病病毒的变异能力使得人们难以捕捉并对付它，“我们利用了病毒的这一行为，通过促进病毒变异率，让病毒本身作为武器攻击自己”。
科学家发现，他们用来杀灭艾滋病病毒所需药物的浓度对细胞无可检测出的毒性，与此同时，用于有效杀灭实验室培养的艾滋病病毒的药物浓度远低于人们用这两种药治疗癌症时的药物浓度。现有获准使用药物被用来开发治疗其他疾病的方法，在医学界被认为是一种低成本和快速获取新药的途径，称为药物重新定位（drug repositioning）。
据悉，胞苷和健泽已获准进行实验鼠的前期临床实验，初期的发现确认，药物可作为艾滋病病毒有效的抗病毒治疗方法。目前科学家正在调整药物，以便组成能够被人体吸收的抗艾滋病病毒口服药。
- 艾滋病早期治疗是康复与延长30～60年生命的保
- 艾滋病免疫重建的重要意义是挽救生命的根本
- 从食品植物研究开发的治疗艾滋病新药三合皂甙
- 康生丹颗粒免疫实验提示符合艾滋病、肿瘤等应
- 鸡尾酒疗法并非万能，抗药性与毒副作用导致联合疗法与中药疗法应用的迫切性
- 康生丹配合西药治疗AIDS总结
- 三合皂甙，康生丹片
- 中药康生丹治愈艾滋病中医论析
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AIDS has also been epoch-making significance of killing the virus is not a problem
http://www.e23.cn2010-8-24 Science and Technology Daily
Abstract: The currently used for early cancer and cancer treatment of the two drugs cytidine (decitabine) and Kin Ze (gemcitabine) with the use, is expected to effectively treat AIDS. Studies in mice animal models, the combination of drugs can lead to AIDS virus mutates and death, scientists call it "fatal variance."
Shun Net News, University of Minnesota Medical Center scientists said they found that the U.S. Food and Drug Administration approval, currently used for early cancer and cancer treatment of the two drugs cytidine (decitabine) and Kin Ze (gemcitabine) with the use of expected effective treatment for AIDS. Studies in mice animal models, the combination of drugs can lead to AIDS virus mutates and death, scientists call it "fatal variance."
The new discovery is significant for AIDS research, because this is the first time looking for people to no toxic side effects to deal with AIDS virus. Scientists believe that since cytidine and health Ze is allowed to use two drugs, so if their studies in a large experimental animal model has been proven effective, then it will be easier to expedite develop drugs for humans.
Study participants include the Institute of Molecular Virology and Molecular virologist 路易斯曼斯基 Dental School, Dr. and Dr. Kristin Lowther, medicinal chemists and drug design center, Dr. Steven Patterson. Mansky said their findings ultimately help the world's 33 million HIV carriers lift the disease offers hope. Related Articles published in the recent "Virology" magazine website.
HIV variation and evolution in the human body rapidly. Now commonly used drugs, primarily role is to inhibit viral growth and replication, consisting of cytidine and health Ze role of new drugs is just the opposite, forcing the virus mutates out of control, and die. Mansky said that the variability of HIV makes it difficult to catch and deal with it, "We use viruses that act, by promoting viral mutation rate, so the virus itself as a weapon to attack itself."
Scientists have discovered that they used to kill the AIDS virus, the concentration of drug needed no detected on the cell toxicity, at the same time, to effectively kill the HIV laboratory culture of drug concentrations much lower than people with two drug concentration during the treatment of cancer. Allowed to use existing drugs are used to develop methods of treatment of other diseases, the medical profession is considered a low-cost and fast way to get new drugs, known as the repositioning of drug (drug repositioning).
It is reported that cytidine and health Ze mice have been allowed to conduct early stage clinical trials, the initial findings confirm that HIV drugs can be used as an effective anti-viral treatment. Scientists are currently the drugs can be absorbed by the body to form the anti-HIV oral medication.
Pharmaceutical and health combined to kill the AIDS virus Ze
Published: 2010-08-24 | author: Mao Li
http://www.stdaily.com 2010 年 08 月 24 First Stage: Journal of Science and Technology: Li Mao
Washington, Aug. 20 (Xinhua Mao Li), University of Minnesota Medical Center scientists said they found the U.S. Food and Drug Administration approval, currently used for early cancer and cancer treatment of the two drugs cytidine (decitabine) and Jian Ze (gemcitabine) with the use, is expected to effectively treat AIDS. Studies in mice animal models, the combination of drugs can lead to AIDS virus mutates and death, scientists call it "fatal variance."
The new discovery is significant for AIDS research, because this is the first time looking for people to no toxic side effects to deal with AIDS virus. Scientists believe that, due to cytidine and health Ze is allowed to use two drugs, so if their studies in a large experimental animal model has been proven effective, then will be easier to accelerate the development of a drug for humans.
Study participants include the Institute of Molecular Virology and Molecular virologist 路易斯曼斯基 Dental School, Dr. and Dr. Kristin Lowther, medicinal chemists and drug design center, Dr. Steven Patterson. Mansky said their findings ultimately help the world's 33 million HIV carriers lift the disease offers hope. Related Articles published in the recent "Virology" magazine website.
HIV variation and evolution in the human body rapidly. Now commonly used drugs, primarily role is to inhibit viral growth and replication, consisting of cytidine and health Ze role of new drugs is just the opposite, it forces the virus mutates out of control, and die out. Mansky said that the variability of HIV makes it difficult to catch and deal with it, "We use viruses that act through the promotion of viral mutation rate, so the virus itself as a weapon to attack itself."
Scientists have found, they used to kill HIV medications De Nongduo no Jiance out on cell toxicity, at the same time, Yong Yu effective Shamie laboratory culture of HIV drug concentration was far below what Yong these two drug concentration during the treatment of cancer. Xian You allowed to use drugs are 用来 development of therapies for other diseases of Fangfa, in the medical profession was considered a low-cost and fast access to new drugs for ways to re-定位 Chen Wei drugs (drug repositioning).
It is reported that cytidine and health Ze mice has been approved for early stage clinical trials, the initial findings confirm that HIV drugs can be used as an effective anti-viral treatment. Scientists are currently the drugs can be absorbed by the body to form the anti-HIV oral medication.
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