艾滋病病毒重组变异趋频繁重组变异亚型已达40多种,大多数在我国有分布
日期:2009-06-19 作者:任荃 来源:文汇报
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本报讯 (首席记者任荃)在宿主与环境的综合作用下,已有28年人类生活史的艾滋病病毒,其重组变异日趋“猖狂”。在昨天举行的上海科普大讲坛第二讲上,上海市疾病预防控制中心终身教授康来仪透露,目前,艾滋病病毒在全球的重组变异亚型多达40多种,其中大多数在我国有分布,这给艾滋病的临床诊断和疫苗研制带来了相当困难。
变异向来是病毒的生存法则,凶险的艾滋病病毒也不例外。全国艾滋病病毒分布状况调查显示,在1996年—1998年间,某种单一亚型占艾滋病病毒种类的一半以上,重组变异亚型较少;到了2001年—2003年间,该单一亚型比例降至29.1%,而重组变异亚型高达50.2%。
重组变异的加速与艾滋病感染传播途径的变化密切相关。康来仪指出,目前,我国新发艾滋病病例以性传播为主,感染比例逐年上升。据全国艾滋病病情哨点监测显示,1985年—2005年的20年间,性传播感染者在艾滋病病例总数中不到10%;去年,这一数字上升到45.8%。这其中,男性同性恋者正在成为不可忽视的高危感染人群。
病毒的耐药性也不断显现。全国艾滋病病毒耐药率监测表明,2004年—2005年,早期和后期一线治疗方案的耐药率分别为20.9%和1.6%;2006年—2007年,两大治疗方案的耐药率分别上升至25.7%和9.2%。耐人寻味的是,不同药物之间竟然出现了交叉感染。比如,一种名为TDF的艾滋病治疗药物在我国尚未使用,就已在实验室中表现出10.2%的高耐药率。
“病毒无需护照,也用不着签证,即可周游全国,环游世界。”康来仪幽默的话语意在向听众传达一个严峻的事实——流动人口将成为艾滋病传播的桥梁人群,长期的流行因素广泛存在。对此,康来仪一再强调国际合作的重要性。“到目前为止,天花是唯一一个被人类消灭的传染病。牛痘的故事告诉我们,战胜传染病需要世界各国的共同努力。”
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AIDS virus more frequent variation
Recombinant subtype has reached more than 40 kinds of variation, the majority of distribution in China
Date :2009-06-19 Author:任荃Source: Wen Wei Po
By (chief reporter任荃) in the host and the environment under the Comprehensive 28-year history of the human AIDS virus, the recombinant variant increasingly "reckless." Held in Shanghai yesterday, popular science talk on the second major forum, the Shanghai Center for Disease Control and Prevention to Professor Miriam Kang said, at present, HIV variation in the global restructuring of up to more than 40 kinds of subtypes, most of which are distributed in China, which to the clinical diagnosis of AIDS and vaccine development is very difficult to bring.
Variation has been the law of the survival of the virus, the risks of HIV is no exception. Distribution of the national HIV survey, in 1996 -1998 years, a single subtype of HIV accounted for more than half of the type, subtype recombinant less variation; the years 2001 -2003, the proportion of a single subtype to 29.1 %, and the reorganization of variation as high as 50.2% subtype.
Accelerate the restructuring of the mutation and transmission of HIV infection is closely related to the change. Kang Lai pointed out that currently, China's new AIDS cases made to the main sexually transmitted infection ratio increased year by year. Condition, according to the National AIDS sentinel surveillance showed that in 1985 -2005 in 20 years, sexually transmitted infections in the total number of AIDS cases in less than 10%; last year, this figure rises to 45.8%. Among these, the male homosexuals is becoming a high risk of infection can not be neglected in the crowd.
HIV drug resistance have been manifested. The national rate of HIV drug resistance monitoring shows that the years 2004 -2005, early and late first-line treatment of drug-resistant rates were 20.9% and 1.6%; in 2006 -2007, the two treatment resistance rate rose to 25.7% and 9.2%. Interestingly, different drugs have actually occurred between the cross-infection. For example, a so-called TDF treatment of AIDS has not yet been used in China, has been demonstrated in the laboratory, 10.2% in the high resistance rate.
"Virus without passports, but also do not need a visa, they can travel around the country, around the world." Kang Lai-yee humorous words intended to convey to the audience the fact that a severe - the floating population will become a bridge for the spread of AIDS groups, the prevalence of long-term factors are widespread . In this regard, to Miriam, Culture and Sport has repeatedly stressed the importance of international cooperation. "So far, smallpox is the only human infectious disease eradication. Vaccinia story tells us that the fight against infectious disease needs the concerted efforts of all countries in the world."
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