据美国物理学家组织网9月20日（北京时间）报道，美国拉特格斯大学研究人员发现，一种变异的
艾滋病病毒HIV-1能够抵抗AZT（叠氮胸苷或齐多夫定，一种广泛用于治疗
艾滋病的防护药物），并在原子水平揭示了变异病毒的抗药机理。科学家认为，这一发现有助于研究人员理解抗艾滋病治疗为什么会无效，进而开发出更加有效的艾滋病治疗方案。研究论文发表在最新一期《
结构与分子生物学》杂志上。
AZT一度是治疗艾滋病的唯一方法，尤其在防止病毒从染病母亲传给未出生婴儿方面发挥着重要作用。HIV病毒需要经由RNA来产生
DNA，从而复制自身。而AZT正是通过阻止一种逆转录酶来发挥作用。大约10年前，几个实验室根据各自的研究就作出推测，将会有一种抗AZT的HIV-1病毒出现。
“研究人员几乎是一开始就知道，病毒发展会抵抗AZT，这种抗性与变异有关，但变异通过什么方式抵抗了药物效力，仍然未知。”主要研究人员化学与生化理事会教授、高等
生物技术与医疗中心成员艾迪·阿诺德说。他们的研究主要是发现了HIV如何通过复杂的变异
行为，提高了自身对药物的抵抗能力，狡猾的HIV-1打败了多年来人们赖以对抗艾滋病的主力药物AZT。
这项研究由美国国家卫生研究院资助。阿诺德与合作者通过X射线晶体衍射技术，在原子尺度分析了抗AZT变异的详细机制。HIV-1病毒并非阻止了AZT发挥作用，而是干脆清除了它。它们利用了细胞中一种最常见的分子ATP（三磷酸腺苷，能在细胞内部运输能量）来清除AZT，实现逆转录。（常丽君）
从预断HIV-1出现,到在原子水平揭示其抗药机理,这或许是人类在与艾魔的对决中逐渐掌握先机和主动的又一标志。在所有相关药物中，AZT对艾滋病病毒的抑制力最强，也最具有价格优势。自从1987年AZT被用于临床治疗，人们便开始关注变异的病毒对它产生抗性，而此抗性早在10多年前就已显现出来。但这一次，科学家们不仅知道其然，而且在卓有成效地探究其所以然。正因为如此，拉特格斯大学这些研究人员才令人刮目相看。自然
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HIV drug resistance mechanism opened ATP removal therapy
At 8:37 on the September 21, 2010 Source: "Technology Daily"
According to the American physicist Organization Network on September 20th (Beijing time) reported that U.S. researchers at Rutgers University found that a mutation of the AIDS virus HIV-1 resistant to AZT (AZT or zidovudine, A widely used to treat AIDS prevention drugs), and revealed at the atomic level mechanism of drug-resistant virus variant. Scientists believe that this discovery will help researchers understand why the ineffective anti-AIDS treatment, and then develop more effective AIDS treatment. Research papers published in the latest issue of "Nature Structural and Molecular Biology" magazine.
AZT treatment of AIDS, once the only way, in particular to prevent the virus from infected mothers to their unborn babies to play an important role. HIV virus by RNA needed to generate DNA, which replicate themselves. The AZT is a kind of reverse transcriptase by preventing role to play. About 10 years ago, several laboratory studies to be made in accordance with their speculation, there will be a resistance to AZT of HIV-1 viruses.
"The researchers knew almost the beginning, the virus will develop resistance AZT, this resistance and mutations, but the variance in what way the effectiveness of the drug resistance is still unknown." Principal investigator, Professor of Chemistry and Biochemistry Council, higher organisms Technology and member of 艾迪阿诺德 Medical Center said. Their study how HIV is found in a complex variation of behavior and improve their resistance to drugs, HIV-1 to defeat the cunning of the fight against AIDS over the years that people rely on the main drugs AZT.
This research was funded by NIH funding. Arnold and collaborators through X ray diffraction technique, the atomic scale analysis of the detailed mechanism of anti-AZT variation. HIV-1 virus does not play a role in AZT prevented, but removing it altogether. They use one of the most common cells in the molecular ATP (adenosine triphosphate, the internal transport of energy in cells) to clear the AZT, to achieve reverse transcription. (Chang Lijun)
HIV-1 from the pre-break appeared to reveal their resistance at the atomic level mechanism, this may be the human magic duel with Ai gradually master the opportunities and initiatives is another sign. In all relevant drugs, AZT inhibition of HIV strongest, and most have a price advantage. Since 1987, AZT has been used in clinical treatment, people began to pay attention to its resistant variant of the virus, and this resistance as early as 10 years ago had revealed. But this time, the scientists not only know the course, but also effective to explore it is exactly. Because of this, the researchers at Rutgers University before impressive.
