含工程细菌的杀菌剂可能抑制艾滋病病毒
www.PharmNet.com.cn 2010-08-24 搜狐健康
生意社8月24日讯 美国和海外研究人员利用人体阴道内生菌开发出一种活性、外用杀菌剂，可以诱导HIV-1（艾滋病病毒）蛋白抑制剂的生成并最终防止该病毒的传播。这项研究的细节发表于2010年7月的《抗菌剂与化疗》杂志上。
在过去的30年中，HIV-1病毒造成了2500万人死亡，全球现在感染HIV-1病毒的人数多达3300万。尽管健康官员正在竭尽全力地努力开发有效的疫苗，但外用抗HIV-1杀菌剂有望作为减少传播的选择性策略。由于活性杀菌剂利用人体内生菌诱导抗HIV-1物质的自然生成，特别受关注。
由于乳酸杆菌（Lactobacillus spp）是女性阴道内的优势菌种，成为活性杀菌剂开发的理想候选菌。在这项研究中，研究人员利用从人体阴道分离出的詹氏乳酸杆菌（Lactobacillus jensenii），通过工程化改造，使其可以产生对抗HIV-1受体蛋白的抗HIV-1蛋白质RANTES和CIC5 RANTES。2种RANTES蛋白质变体均可抑制HIV-1感染，并对多种HIV-1遗传亚型有显著的抑制作用。
“这项研究为工程化阴道共生菌有效分泌抗HIV-1活性CCR5拮抗剂提供了原理验证，这是迈向实用、安全、低成本的性传播HIV-1预防的重要进展。”研究人员表示。（姚立新）
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Engineering bacteria containing fungicides may inhibit HIV
www.PharmNet.com.cn 2010-08-24 Sohu Health
Business community on August 24 The U.S. and overseas researchers have used human vaginal plate to develop an active, topical microbicides, can induce HIV-1 (AIDS virus) protein inhibitors of the generation and ultimately to prevent the spread of the virus. Details of the study published in July 2010 of "anti-bacterial agents and chemotherapy," magazines.
In the past 30 years, HIV-1 virus resulted in 2,500 people dead, the world is now infected with HIV-1 virus, as many as 33 million. Although health officials are making every effort to develop an effective vaccine, but topical microbicides against HIV-1 is expected to reduce transmission as a selective strategy. As the activity of fungicides used in the human body plate against HIV-1 induced by naturally occurring substances, in particular concern.
As the lactic acid bacteria (Lactobacillus spp) is the dominant species of female vagina, into the development of active fungicide ideal candidate bacteria. In this study, the researchers used isolated from human vaginal Lactobacillus Jane (Lactobacillus jensenii), modified by engineering so that it can produce against the HIV-1 receptor protein in the anti-HIV-1 proteins RANTES and CIC5 RANTES . Two kinds of RANTES protein variants can inhibit HIV-1 infection, and a variety of HIV-1 genetic subtypes were significantly inhibited.
"This research project of the vaginal secretion of symbiotic bacteria and effective against HIV-1 activity of CCR5 antagonists provides system verification, which is towards the practical, safe, low-cost sexually transmitted HIV-1 prevention of significant progress." Researchers say . (YAO Li-xin)
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