最近，美国电子工程学家埃道甘-奥兹坎（Aydogan Ozcan）领导的实验室制造了一部具有特殊功能的原型手机：既可用于监测艾滋病、疟疾患者的身体状况，也可用于检测欠发达或受灾地区的水质。在这部手机上，研究人员引入了一种创新性成像技术，而发明这项技术的正是目前任职于加利福尼亚大学伯克利分校的奥兹坎教授。
可打电话还可监测艾滋病的新型手机
奥兹坎教授发明的技术名为“基于侧影成像的无透镜超宽视野单元监测阵列”（(Lensless Ultra-wide-field Cell monitoring Array platform based on Shadow imaging，简称 LUCAS），目前已成功应用于上述手机和网络摄像头上。不论是手机还是摄像头，其实都采用的是同一种成像方式：利用短波长蓝光照射血液、唾液或其他液体样品，再通过一个传感器阵列，捕捉样品中的微粒图像。
由于液体样品中的不同微粒拥有不同衍射图谱（diffraction pattern），因此通过决策算法（custom-developed），与已有微粒图谱库进行对比，LUCAS很快就能鉴定出样品中的微粒类型。然后，人们就可以使用手机，将LUCAS采集到的数据发往医院以供进一步分析和诊断，或利用USB接口把数据转移到电脑上，再发往医疗机构。
不过，LUCAS手机并非显微镜的替代品，而是一种补充工具。与LUCAS产生的粒状和像素化图像相比，显微镜下的图像更为细腻。但LUCAS也有自身优势：在很多情况下，人们不可能随时携带显微镜，而LUCAS手机却能及时鉴定液体样品中的微粒类型，并完成计数。另外，由于LUCAS成像不需要镜头，因此只有一个因素能限制LUCAS手机的尺寸：构建LUCAS的芯片大小。
奥兹坎教授教授说：“LUCAS技术不仅能用于健康医疗领域，在细胞生物学领域也有很好的应用前景。通常，研究人员统计血液中的细胞数量时，都是用流式细胞仪（flow-cytometer），一次只能记录一个细胞，而LUCAS成像却可以同时记录成千上万个细胞，准确率也不比流式细胞仪差。”
2008年12月5日，奥兹坎教授在《芯片实验室》杂志（Lab on a Chip）上发表文章称，经过一系列改进，他制造出了第二代LUCAS系统——全息LUCAS（holographic LUCAS）。改进后，全息LUCAS可以鉴定更微小的颗粒，比如大肠杆菌，这是第一代LUCAS无法做到的。通过改变光源的空间位置，全息LUCAS捕捉到的二维微粒影像会比经典微粒成像含有更多的信息。
奥兹坎教授未来几年的计划是，把LUCAS系统真正融入手机等手持设备。有了这些设备，人们即使在偏远地区，也能及时监控疾病的流行情况，让医疗机构能针对重点地区
做好防治工作。另外，LUCAS系统也能用于监测水质，比如检测饮用水中的有害微粒。LUCAS系统在日本展出后，东京大学和九州大学的科学家还曾与奥兹坎教授联系，希望能将该系统用于抗震救灾。（环球科学编译 褚波）
手机第二春将来临 竟可测试艾滋病毒？
2008年12月25日18:59 来源：小熊在线 作者：Dreamcatcher
日前据美国科学家最新研究表明，我们日常使用的手机除了打电话发短信和上网之外，又多了一个全新的用途：健康监测仪。
AydoganOzcan是加利福尼亚大学的一名教授。
它表示，目前的手机使用无透镜成像技术后，可在某些不发达国家被用作HIV、疟疾或水源测试仪器。Ozcan甚至制造了一个搭载了LUCAS（无透镜超广角单元监视阵列）无透镜平台的手机原型。该技术的原理和摄像头类似，只不过是使用波长较短的蓝光来照亮血液、唾液或其它流体样品。拍摄后的数据可以传输到医院进行分析研究。
这玩意儿的摄像头真能拍到你的细胞？
Ozcan在一份声明中说，“该技术不仅会对医疗卫生事业产生重大的影响，而且能够降低某些血细胞试验的成本。常规的流式细胞仪仅能识别连续的单个细胞，但是LUCAS却能够同时识别数千个细胞，而且精确度与前者相同。”
据悉，Aydogan Ozcan的这一发现已被刊登在《芯片上的实验室》（Lab on a Chip）上。 (责任编辑：罗园)
12 years http://tech.QQ.com 2008 on 14:15 on 25 I would like to comment on Global Science (0)
Recently, the U.S. electronic engineer and Egypt Gan Road - Ao Zikan (Aydogan Ozcan) led by the laboratory to create a special functional prototype phone: can be used to monitor AIDS, malaria patient's physical condition can also be used to detect due to Developed or the water quality in the affected areas. In this mobile phones, the researchers introduced an innovative imaging technology, and the invention of this technology is currently serves on the University of California at Berkeley Professor of Aozi Kan.
Monitoring AIDS can also call a new phone
Click here to watch more brilliant picture
Aozi Kan, a professor of technical invention "based on the silhouette image of the lens with wide field of vision monitoring unit array" ((Lensless Ultra-wide-field Cell monitoring Array platform based on Shadow imaging, referred to as LUCAS), has been successfully applied to Network cameras and cell phones above their heads. Be it cell phone or camera, in fact, have used the same image: the use of short-wavelength blue light exposure to blood, saliva or other fluid samples, and then through a sensor array, to capture samples of Particle image.
As the liquid samples in the different particles have different diffraction patterns (diffraction pattern), therefore, the adoption of the decision-making algorithm (custom-developed), Treasury mapping and particles has been compared, LUCAS will be able to quickly identify the type of particles in the sample. Then, people will be able to use cell phones, LUCAS will be collected data sent to hospital for further analysis and diagnosis, or use USB interface to transfer data to the computer, and then sent to medical institutions.
However, LUCAS phone microscope is not a substitute for, but a supplementary tool. LUCAS and have a granular and pixel of the image, the image under the microscope even more delicate. LUCAS, but also to its own advantages: In many cases, people can not carry a microscope at any time, and in a timely manner LUCAS phone can identify liquid particles in the sample type, and completion of the count. In addition, due to the need LUCAS imaging lens, so there is only one factor to limit the size of the mobile phone LUCAS: to build chips LUCAS size.
Professor Aozi Kan said: "LUCAS technology can be used not only in the field of health care in the field of cell biology has become a good prospect. Typically, researchers Statistics blood cells, are using flow cytometry ( flow-cytometer), a record of only one cell, and LUCAS imaging can be recorded at the same time thousands of cells, the accuracy is not worse than the flow cytometer. "
December 5, 2008, Aozi Kan, a professor at the "lab chip" magazine (Lab on a Chip) published an article saying that after a series of improvements, he created a second-generation system LUCAS - holographic LUCAS (holographic LUCAS ). The improved, LUCAS hologram can be identified more tiny particles, such as E. coli, which is the first generation LUCAS can not do. By changing the spatial location of the light source, holographic LUCAS captured images of two-dimensional particles than the classic image particles containing more information.
Aozi Kan, a professor in the next few years the plan is that the system really LUCAS into handheld devices such as mobile phones. With such equipment, even people in remote areas, and in a timely manner to monitor the prevalence of the disease so that medical institutions can focus on the key areas
Do a good job in prevention and treatment. In addition, LUCAS system can also be used to monitor water quality, such as the detection of harmful particles in drinking water. LUCAS display system in Japan, Kyushu University and the University of Tokyo scientists had contact with the Aozi Kan, a professor in the hope of the system for earthquake relief. (Universal Scientific compiled Chu Bo)
Second was the advent of mobile phones will be tested for HIV?
At 6:59 p.m. on December 25, 2008 Source: Cubs Online Author: Dreamcatcher
A few days ago, according to latest research shows that American scientists, we have day-to-day use of mobile phones in addition to phone calls and send text messages and Internet access, the addition of a new purpose: Health Monitor.
AydoganOzcan is a professor at the University of California.
It said that the current mobile phone lenses without the use of imaging technology, some of the least developed countries can be used as HIV, malaria or water testing equipment. Ozcan and even created a board of the LUCAS (non-ultra-wide-angle lens surveillance unit arrays) without lens prototype mobile phone platform. The principles and techniques similar to the camera, just use a shorter wavelength blue light to illuminate the blood, saliva or other fluid samples. After the shooting data can be transferred to the hospital for analysis.
This camera stuff can really get your cell?
Ozcan said in a statement, "This technology will not only medical and health undertakings have a major impact, and can reduce some of the blood cell test costs.'s Conventional flow cytometry in a row only to identify a single cell, but it can LUCAS At the same time, thousands of cells to identify and to the same accuracy. "
It is reported that, Aydogan Ozcan of this discovery has been published in the "lab on a chip" (Lab on a Chip) on. (Editor: Luo Park)