美研究用合成蛋白质阻断艾滋病病毒感染

美研究用合成蛋白质阻断艾滋病病毒感染
2009年08月21日 09:12新华网
新华网洛杉矶8月20日电（记者高原）美国研究人员在最新一期美国《国家科学院学报》上报告说，他们在实验中利用一种合成蛋白质成功阻断了艾滋病病毒对健康细胞的入侵。这一成果将有助于研发出新的抗艾滋病药物。

美国威斯康星大学麦迪逊分校的一个研究小组介绍说，他们合成的这种蛋白质可以抑制艾滋病病毒的关键蛋白质ｇｐ41，使其不能与宿主细胞中的蛋白质发生交互作用，从而使病毒无法顺利入侵细胞。

研究人员解释说，ｇｐ41和宿主细胞内蛋白质的交互作用是艾滋病病毒感染并破坏人体细胞过程中的关键一环。过去科研人员曾研发各种药物，试图阻止这二者通过接触而产生相互作用，但都收效不大。一些药物中用来抑制ｇｐ41的合成蛋白质虽然部分有效，但体内的酶又会破坏其结构，使其不能发挥作用。

最新开发出的合成蛋白质由于在结构上作出了特殊改变，体内的酶根本就无法识别它。这种蛋白质有所“伪装”，同时又保存了原本的立体结构，从而可以顺利完成识别并抑制ｇｐ41的任务。

研究人员称，这一新成果不仅可以应用于对艾滋病的防治，也可应用于对流感病毒、埃博拉病毒等的防治，因为这些病毒都是通过蛋白质的交互作用而感染机体的。

U.S. study of protein synthesis block HIV infection
At 9:12 on August 21, 2009 Xinhuanet
Xinhua Los Angeles, August 20 (Xinhua plateau) U.S. researchers in the latest issue of the United States, "Journal of the National Academy of Sciences" reports that they use in the experiment a success of protein synthesis blocked the AIDS virus's invasion of healthy cells. The results will help to develop new anti-AIDS drugs.

University of Wisconsin-Madison United States of a research group said that their synthesis of protein can inhibit a key HIV protein gp41, so that it can not be with the host cell protein interaction occurred, so that the virus can not successfully invade cells.

The researchers explained that, gp41 and the host cell protein interaction is and destroy HIV-infected human cells in the process of a key element. Over the past researchers have developed a variety of drugs, tried to prevent both contact generated through the interaction, but with little success. Some drugs used to inhibit the synthesis of gp41 protein although some effective, but the body's enzymes will destroy its structure, so that they can not play a role.

The synthesis of the latest development in the structure of proteins to make a special change in the body's enzymes do not recognize it. This protein has been "disguised", at the same time to preserve the original three-dimensional structure, so that we can identify and successfully completed the task of inhibiting gp41.

The researchers said the new results can be applied not only to the prevention and treatment of AIDS, but also can be applied to the influenza virus, Ebola virus, such as the prevention and treatment, because these viruses are protein interaction through the infected organism.