|
美研究者用基因技术遏制艾滋病病毒
2010年07月04日 09:17:27 来源： 新华网
新华网洛杉矶７月２日专电（记者高原）美国科研人员最近利用基因技术成功遏制老鼠体内的艾滋病病毒，这一方法为控制艾滋病病毒增殖提供了新思路。
这一技术的关键在于负责指导合成ＣＣＲ５蛋白的一种基因。ＣＣＲ５蛋白是艾滋病病毒入侵机体细胞的“帮凶”。科研人员很早就发现，如果ＣＣＲ５蛋白基因发生有利的变异，那么人体就可能出现针对艾滋病病毒的免疫抵抗力。
美国南加州大学的葆拉·坎农等人在新一期英国《自然－生物工艺学》杂志上报告说，他们用老鼠做实验时，借助一种名为ｃｕｔｔｅｒ的酶，删除了未成熟造血细胞中的ＣＣＲ５蛋白基因，因此这些细胞成熟分化时不会产生ＣＣＲ５蛋白。
研究人员把这些细胞注入感染了艾滋病病毒的老鼠体内，并把它们与感染艾滋病病毒的普通老鼠进行比较，结果发现１２周后在接受注射的老鼠体内，免疫Ｔ细胞水平有所恢复，艾滋病病毒含量保持在较低水平。而对照组老鼠的免疫系统能力减弱，艾滋病病毒大量分裂增殖。
坎农说，科研人员今后面临的挑战是如何将这一基因治疗技术用于人类。（完）
- 艾滋病早期治疗是康复与延长30～60年生命的保
- 艾滋病免疫重建的重要意义是挽救生命的根本
- 从食品植物研究开发的治疗艾滋病新药三合皂甙
- 康生丹颗粒免疫实验提示符合艾滋病、肿瘤等应
- 鸡尾酒疗法并非万能，抗药性与毒副作用导致联合疗法与中药疗法应用的迫切性
- 公布几例康生丹治疗艾滋病的检测报告照片
- 康生丹配合西药治疗AIDS总结
- 三合皂甙，康生丹片
- 中药康生丹治愈艾滋病中医论析
-
-
U.S. researchers used gene technology to curb HIV
July 4, 2010 09:17:27 Source: Xinhua
LOS ANGELES, July 2 (Xinhuanet plateau) American researchers recently used gene technology successfully contained the virus in mice, this approach to control HIV proliferation provides a new idea.
This technology is the key protein responsible for directing the synthesis of a CCR5 gene. CCR5 protein is the AIDS virus from entering body cells "accomplice." Researchers have long found that if a favorable CCR5 gene variation may occur if the body's immune resistance against HIV.
University of Southern California's Paula Lakhan farmers and others in the new issue of the British "Nature - Biotechnology," the magazine reported that when they experiment with mice, with the help of enzymes called cutter to remove the immature hematopoietic cells in the CCR5 gene, these cells mature and differentiate will not produce CCR5 protein.
The researchers injected these cells infected with the AIDS virus, mice, and infected them with HIV compared normal mice was found after 12 weeks, vaccinated mice, the level of immune T cells in some restoration, HIV levels kept low. The control group weakened immune system of mice, a large number of proliferation of the AIDS virus.
Cannon said that the future challenges facing researchers is how this technology for human gene therapy. (END)
|
