上述案例首次被公之于众是在2008年波士顿举行的逆转录病毒以及机会感染会议上。之后,柏林的医务人员在2009年2月的新英格兰医学杂志(New England Journal of Medicine )上详细地介绍了这个案例。关键在于移植到病人体内的骨髓很特殊---它来自于一个先天对HIV病毒免疫的骨髓捐赠者。先天免疫是因为此人特殊的基因档案(genetic profile)使得它体内不存在艾滋病毒赖以传播的CCR5辅助受体。CCR5是一种趋化因子,在HIV体内传播中它的作用就如同笔记本电脑的“充电基座”,大部分HIV病毒必须附着在它之上才能进入并感染CD4细胞。(CD4 是一种T细胞,HIV病毒感染并破坏它---译者)
In 2007,oneinfected withHIVvirusin Berlinto acceptaleukemiastem celltransplant.As the doctorcantransplantthestem cellsagainst HIV, and tosuccessfullycured himof HIVinfection.Thedoctorsin charge of thecaseconfirmed the newsrecently.
Thecasewas firstmade publicin 2008, heldin Boston, andopportunistic infectionsretrovirusconference.After themedical staffin Berlinin February 2009the New EnglandJournal of Medicine(New England Journal of Medicine)on thedetailed description ofthe case.The keyis totransplantinto the patient'sbone marrowis very special---it comes fromaninnateimmunityagainstHIV,bone marrowdonor.Innate immunitybecausethe persona specialgenetic profile(genetic profile)so that itdoes not existin vivowhichthe spread ofHIVcoreceptorCCR5.CCR5isa chemokine, in thespread ofHIVinthe bodyitacts like anotebook computer, "charging base, "most of theHIVvirusmust beattachedon top of itto enterand infectCD4cells.(CD4is aTcell, HIVinfectionand destroyit---Translator)
Medical staffin Berlinrecentlypublished in the journalBloodafollow-up report, claiming thatafter carefultesting,"have every reason todeterminetheHIVinfectioncases have beencompletely cured. "
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