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美研究发现一种常见化合物能抑制艾滋病病毒
2009年03月05日 18:06:19 来源：新华网
新华网华盛顿３月５日电 美国科学家最新研究发现，一种常用于食品和化妆品中的廉价化合物，可以帮助猴子阻断猴免疫缺陷病毒（即猴子版本的艾滋病病毒）的传播。这一发现有望为人类预防艾滋病病毒感染提供新方法。
明尼苏达大学研究小组在５日出版的新一期英国《自然》杂志上报告说，他们在以雌猴为对象进行的实验中发现，月桂酸单甘油酯（简称ＧＭＬ）可以有效帮助雌猴避免感染猴免疫缺陷病毒（ＳＩＶ）。
实验中，研究人员选了１０只雌猴分为两组，给其中５只雌猴的阴道注入一种含有月桂酸单甘油酯的凝胶处理液，另外５只作为对照组。然后，这些猴子体内均被注入一定剂量的ＳＩＶ病毒。
随后两个星期的观察显示，对照组５只猴子全部感染了ＳＩＶ，而使用月桂酸单甘油酯处理过的猴子只有１只被感染。
月桂酸单甘油酯是天然存在于一些植物中的化合物，提取之后经常作为杀菌剂及消炎剂添加到食品、日用品或化妆品中。《自然》杂志介绍说，此前也曾有研究小组尝试用不同的杀菌剂抑制艾滋病病毒感染，但效果均令人失望，而月桂酸单甘油酯则表现出了明显的抑制艾滋病病毒的效果。
研究小组强调说，月桂酸单甘油酯的最大优势在于它十分廉价，一旦证实也能有效阻断人体艾滋病病毒传播，就有望研制出便宜的、用于女性的艾滋病预防药物。另外，除了艾滋病以外，这种化合物可能还有阻断其他性传播疾病感染的作用。
不过，他们也表示，利用月桂酸单甘油酯进行人体临床试验前，还需要进行大量实验分析工作。
U.S. study found that a common compounds can inhibit HIV
March 5, 2009 18:06:19 Source: Xinhuanet
Xinhua Washington, March 5 The United States electricity the latest research scientists found that a commonly used in food and cosmetics cheap compounds, can help block the monkey simian immunodeficiency virus (that is, a monkey version of HIV) transmission. The discovery is expected to human prevention of HIV infection to provide new methods.
Group at the University of Minnesota published a new 5 day a British "Nature" magazine reported that they object to female monkeys for experiments found that lauric acid monoglyceride (referred to as GML) can effectively assist females to avoid infected with simian immunodeficiency virus (SIV).
Experiments, the researchers selected 10 female monkeys were divided into two groups, give one of five female monkeys injected into the vagina containing a monoglyceride of lauric acid gel treatment fluid, the other five as a control group. And, these monkeys were injected in vivo dose must SIV virus.
Followed by two weeks of observation revealed that the control group all five monkeys infected with SIV, the use of lauric acid monoglyceride-treated monkeys, only one infected.
Lauric acid monoglyceride are present in some natural plant compounds, after extraction often as fungicides and anti-inflammatory agent is added to food, daily necessities, or in cosmetics. "Nature" magazine, said after Group also has experimented with different fungicides inhibit HIV infection, but the results were disappointing, and lauric acid monoglyceride showed significant inhibition of HIV results.
Group emphasized that lauric acid monoglyceride greatest advantage is that it is very cheap, once confirmed will effectively block the human AIDS virus, it is expected to develop cheaper for women's AIDS prevention drug. In addition, other than apart from AIDS, the compounds may also block other sexually transmitted diseases the role of infection.
However, they also said that the use of lauric acid monoglyceride before human clinical trials, but also required a great deal of experimental analysis.
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