美研究发现帮助艾滋病病毒复制的基因

美研究发现帮助艾滋病病毒复制的基因
2009年12月07日 13:56:23 　来源：新华网
新华网华盛顿１２月６日电（记者任海军）美国研究人员６日报告说，他们发现了帮助艾滋病病毒在人体内传播和复制的基因，这项成果将有望应用于开发治疗艾滋病的新药或疫苗。

研究人员介绍说，他们发现的基因位于艾滋病病毒核糖核酸基因序列中，与人体内的ｔＲＮＡＬｙｓ基因非常相似。正是由于这一基因的存在，艾滋病病毒才能在人体内以更高的效率复制。

负责这项研究的美国罗切斯特大学教授罗伯特·班巴拉等人６日在英国《自然·结构和分子生物学》杂志网络版上发表文章指出，确定这一基因的来源可为艾滋病病毒起源的研究提供有价值的线索。

艾滋病病毒是一种逆转录病毒，依赖核糖核酸携带并执行遗传指令，使病毒能够侵入并征服宿主细胞。科学家们普遍认为，人类艾滋病病毒由猿类免疫缺陷病毒（ＳＩＶ）进化而来。班巴拉等人则指出，ＳＩＶ被认为起源于猫科免疫缺陷病毒，因此后者可能是人类艾滋病病毒的祖先之一。

    美国国家卫生研究院科学家马修·波特努瓦认为，这一研究有助于理解病毒的进化，其意义不仅限于艾滋病病毒，对理解甲型Ｈ１Ｎ１流感病毒如何跳跃数个物种并分别获取它们的基因片段也有裨益。
The study found the United States to help AIDS virus replication genes
December 7, 2009 13:56:23 Source: Xinhua
    WASHINGTON, December 6 (Xinhua Ren Navy) 6, U.S. researchers reported that they found the AIDS virus in the human body to assist the dissemination and replication of genes, the results will be expected to be used to develop a new drug or vaccine to treat AIDS .

    The researchers said they found the genes in the genome sequences of HIV RNA, and the human body tRNALys genetically very similar. Because of the presence of the gene, HIV can be in the human body more efficient replication.

    In charge of the research professor at the University of Rochester, Robert Bambara and others on the 6th in the UK, "Nature Structural and Molecular Biology" magazine online edition published an article that identified the source of the gene for the origin of AIDS virus provide valuable clues.

    HIV is a retrovirus-dependent RNA to carry and execute genetic instructions, so that the virus can invade and conquer the host cells. Scientists generally believe that the human AIDS virus from simian immunodeficiency virus (SIV) evolved. Bambara and others pointed out, SIV are thought to arise feline immunodeficiency virus, so the latter may be one of the ancestors of the human AIDS virus.

    U.S. National Institutes of Health scientist Matthew Portnoi believe that this study helps to understand the evolution of the virus, its significance is not limited to HIV, influenza A H1N1 influenza virus in understanding how to jump a number of species and to obtain their respective gene fragment is also beneficial.